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Signal sequence mutations that alter coupling of secretion and translation of an Escherichia coli outer membrane protein

Benson, S. A. and Hall, M. N. and Rasmussen, B. A.. (1987) Signal sequence mutations that alter coupling of secretion and translation of an Escherichia coli outer membrane protein. Journal of bacteriology, Vol. 169, H. 10. S. 4686-4691.

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Official URL: http://edoc.unibas.ch/dok/A5258206

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Abstract

The lamB701-708 signal sequence mutation reduces expression of LamB, an outer membrane protein of Escherichia coli. To investigate the possibility that synthesis and export of LamB are coupled, as suggested by the expression defect of the lamB701-708 mutation, we isolated intragenic suppressors of the lamB701-708 mutation. The expression defect imposed by the lamB701-708 mutation is suppressed by an export-defective signal sequence mutation, suggesting that translation and export are coupled. The additional observation that not all export-defective signal sequence mutations suppressed the lamB701-708 expression defect suggests that translational arrest can be uncoupled from export.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:American Society for Microbiology
ISSN:1098-5530
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:20
Deposited On:22 Mar 2012 13:19

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