Khorshid, Mohsen and Hausser, Jean and Zavolan, Mihaela and van Nimwegen, Erik. (2013) A biophysical miRNA-mRNA interaction model infers canonical and noncanonical targets. Nature methods, Vol. 10, H. 3. pp. 253-255.
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Official URL: http://edoc.unibas.ch/dok/A6094019
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Abstract
We introduce a biophysical model of miRNA-target interaction and infer its parameters from Argonaute 2 cross-linking and immunoprecipitation data. We show that a substantial fraction of human miRNA target sites are noncanonical and that predicted target-site affinity correlates well with the extent of target destabilization. Our model provides a rigorous biophysical approach to miRNA target identification beyond ad hoc miRNA seed-based methods.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (Zavolan) |
|---|---|
| UniBasel Contributors: | Zavolan, Mihaela and van Nimwegen, Erik |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Nature Publishing Group |
| ISSN: | 1548-7091 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 24 May 2013 09:17 |
| Deposited On: | 26 Apr 2013 06:54 |
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