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Cellular therapy of systemic lupus erythematosus

Tyndall, A.. (2009) Cellular therapy of systemic lupus erythematosus. Lupus, 18 (5). pp. 387-393.

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Official URL: http://edoc.unibas.ch/dok/A6003930

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Abstract

Immunoablation with autologous hematopoietic stem cell rescue has been used in over 1,300 autoimmune disease patients, around 150 with SLE. Some patients have experienced durable remissions with loss of autoantibodies, whereas others either did not respond or died as a result of the treatment. Prospective randomised trials are required and are being planned to establish the place for this potentailly curative strategy. Mesenchymal stem cells are in an exploratory phase for the treatment of acute autoimmune disease including SLE. The principle is that they home to inflammed tissue and exert an antiinflammatory paracrine effect.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Rheumatologie FPS (Tyndall)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Rheumatologie FPS (Tyndall)
03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Rheumatologie FPS (Tyndall)
UniBasel Contributors:De Vere-Tyndall, Alan
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:SAGE
ISSN:0961-2033
e-ISSN:1477-0962
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:02 Nov 2017 09:26
Deposited On:01 Mar 2013 11:13

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