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Concordant colon tumors in monozygotic twins previously treated for prostate cancer

Templeton, Arnoud and Marra, Giancarlo and Valtorta, Emanuele and Heinimann, Karl and Müller, Hansjakob and Köberle, Dieter and Gillessen, Silke. (2009) Concordant colon tumors in monozygotic twins previously treated for prostate cancer. Familial cancer, Vol. 8. S. 167-171.

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Official URL: http://edoc.unibas.ch/dok/A6006322

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Abstract

This report describes the quasi-simultaneous occurrence of colon cancers in monozygotic twin brothers (age 63 years) who had undergone androgen deprivation therapy for prostate cancers 4 years earlier. Concordance among male twins for both of these cancers has never been reported. Although the family history suggested possible genetic predispositions to both cancers, the twins have no evidence of the genetic alterations associated with hereditary colorectal tumors. We explore the possibility that colorectal tumorigenesis in these twins was fuelled by a combination of genetic and iatrogenic factors, in particular the androgen deprivation therapy used to treat their prostate cancers.
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Medizinische Genetik (Miny)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Medizinische Genetik (Miny)
UniBasel Contributors:Heinimann, Karl
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:1389-9600
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Mar 2013 11:13
Deposited On:01 Mar 2013 11:08

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