Balwierz, Piotr J.. Inference of gene regulatory interactions from deep sequencing data. 2012, PhD Thesis, University of Basel, Faculty of Science.
Official URL: http://edoc.unibas.ch/diss/DissB_10245
In the second part we focus on the regulatory functions of two small nucleolar RNAs (snoRNAs). In Chapter 8 we describe an atypical function of snoRNAs - regulation of the mRNA alternative splicing process by a particular class of mouse snoRNAs (MBII-52 variants). These are of great interest, as the locus encoding MBII-52 is linked to Prader-Willi Syndrome. Methods include in silico RNA hybridization screens and experimental confirmation of the predictions. In Chapter 9, we report a discovery of the first virus-encoded snoRNA in Epstein-Barr Virus (EBV). Again, we show that the function of this snoRNA (v-snoRNA1) is atypical: it is processed into small, 24 nt long fragments that can function as microRNAs.
|Advisors:||Nimwegen, Erik van|
|Committee Members:||Schübeler, Dirk|
|Faculties and Departments:||05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (van Nimwegen)|
|Bibsysno:||Link to catalogue|
|Number of Pages:||273 S.|
|Last Modified:||30 Jun 2016 10:51|
|Deposited On:||12 Feb 2013 10:48|
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