Romanino, Klaas Emilio Antonius Anna. The role of mTOR complex 1 in skeletal muscle. 2012, PhD Thesis, University of Basel, Faculty of Science.
Official URL: http://edoc.unibas.ch/diss/DissB_10185
Additional metabolic changes in mTORC1-deficient muscle include glucose metabolism. Mice with inactivated mTORC1 in muscle show accumulations of glycogen, accompanied by a significant reduction of glucose uptake and glycolysis. The glycogen content is regulated through the activation of PKB/Akt, independently of PGC-1α. The reduction of glucose metabolism, in turn, correlates with an upregulation of the class II HDACs.
Besides inefficient nutrient uptake, mice lacking muscle mTORC1 increase their energy expenditure, which might be due to an upregulation of UCPs. Together, these metabolic changes lead to a protection against diet-induced obesity and hepatic steatosis. Thus, the mTORC1 is a central hub of metabolic pathways in skeletal muscle affecting systemic energy homeostasis.
|Advisors:||Rüegg, Markus A.|
|Committee Members:||Handschin, Christoph|
|Faculties and Departments:||05 Faculty of Science > Departement Biozentrum > Neurobiology > Pharmacology/Neurobiology (Rüegg)|
|Bibsysno:||Link to catalogue|
|Number of Pages:||77 Bl.|
|Last Modified:||30 Jun 2016 10:51|
|Deposited On:||28 Nov 2012 15:42|
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