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African 2, a clonal complex of Mycobacterium bovis epidemiologically important in East Africa

Berg, S. and Garcia-Pelayo M. C., and Müller, B. and Hailu, E. and Asiimwe, B. and Kremer, K. and Dale, J. and Boniotti, B. and Rodriguez, S. and Hilty, M. and Rigouts, L. and Firdessa, R. and Machado, A. and Mucavele, C. and Ngandolo, B. N. and Bruchfeld, J. and Boschiroli, L. and Muller, A. and Sahraoui, N. and Pacciarini, M. and Cadmus, S. and Joloba, M. and van Soolingen D., and Michel, A. L. and Djonne, B. and Aranaz, A. and Zinsstag, J. and van Helden P., and Portaels, F. and Kazwala, R. and Källenius, G. and Hewinson, R. G. and Aseffa, A. and Gordon, S. V. and Smith, N. H.. (2011) African 2, a clonal complex of Mycobacterium bovis epidemiologically important in East Africa. Journal of bacteriology : a publication of the American Society for Microbiology, Vol. 193, H. 3. S. 670-678.

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Official URL: http://edoc.unibas.ch/dok/A6002100

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Abstract

We have identified a clonal complex of Mycobacterium bovis isolated at high frequency from cattle in Uganda, Burundi, Tanzania, and Ethiopia. We have named this related group of M. bovis strains the African 2 (Af2) clonal complex of M. bovis. Af2 strains are defined by a specific chromosomal deletion (RDAf2) and can be identified by the absence of spacers 3 to 7 in their spoligotype patterns. Deletion analysis of M. bovis isolates from Algeria, Mali, Chad, Nigeria, Cameroon, South Africa, and Mozambique did not identify any strains of the Af2 clonal complex, suggesting that this clonal complex of M. bovis is localised in East Africa. The specific spoligotype pattern of the Af2 clonal complex was rarely identified among isolates from outside Africa and the few isolates that were found and tested were intact at the RDAf2 locus. We conclude that the Af2 clonal complex is localised to cattle in East Africa. We found that strains of the Af2 clonal complex of M. bovis have, in general, four or more copies of the insertion sequence IS6110 in contrast to the majority of M. bovis strains isolated from cattle that are thought to carry one, or few copies, only
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Human and Animal Health > One Health (Zinsstag)
UniBasel Contributors:Zinsstag, Jakob Z
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:American Society for Microbiology
ISSN:1098-5530
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:23
Deposited On:08 Nov 2012 16:21

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