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The GABRIEL Advanced Surveys: study design, participation and evaluation of bias

Genuneit, J. and Büchele, G. and Waser, M. and Kovacs, K. and Debinska, A. and Boznanski, A. and Strunz-Lehner C., and Horak, E. and Cullinan, P. and Heederik, D. and Braun-Fahrländer C., and von Mutius E., and Gabriela Study Group, . (2011) The GABRIEL Advanced Surveys: study design, participation and evaluation of bias. Paediatric and perinatal epidemiology, Vol. 25, H. 5. S. 436-447.

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Official URL: http://edoc.unibas.ch/dok/A6002373

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Abstract

Genuneit J, Buchele G, Waser M, Kovacs K, Debinska A, Boznanski A, Strunz-Lehner C, Horak E, Cullinan P, Heederik D, Braun-Fahrlander C, von Mutius E, the GABRIELA Study Group. The GABRIEL Advanced Surveys: study design, participation and evaluation of bias. Paediatric and Perinatal Epidemiology 2011; 25: 436-447. Exposure to farming environments has been shown to protect substantially against asthma and atopic disease across Europe and in other parts of the world. The GABRIEL Advanced Surveys (GABRIELA) were conducted to determine factors in farming environments which are fundamental to protecting against asthma and atopic disease. The GABRIEL Advanced Surveys have a multi-phase stratified design. In a first-screening phase, a comprehensive population-based survey was conducted to assess the prevalence of exposure to farming environments and of asthma and atopic diseases (n = 103 219). The second phase was designed to ascertain detailed exposure to farming environments and to collect biomaterial and environmental samples in a stratified random sample of phase 1 participants (n = 15 255). A third phase was carried out in a further stratified sample only in Bavaria, southern Germany, aiming at in-depth respiratory disease and exposure assessment including extensive environmental sampling (n = 895). Participation rates in phase 1 were around 60% but only about half of the participating study population consented to further study modules in phase 2. We found that consenting behaviour was related to familial allergies, high parental education, wheeze, doctor diagnosed asthma and rhinoconjunctivitis, and to a lesser extent to exposure to farming environments. The association of exposure to farm environments with asthma or rhinoconjunctivitis was not biased by participation or consenting behaviour. The GABRIEL Advanced Surveys are one of the largest studies to shed light on the protective 'farm effect' on asthma and atopic disease. Bias with regard to the main stud question was able to be ruled out by representativeness and high participation rates in phases 2 and 3. The GABRIEL Advanced Surveys have created extensive collections of questionnaire data, biomaterial and environmental samples promising new insights into this area of research
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Pädiatrie (Frey)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Pädiatrie (Frey)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Physical Hazards and Health (Röösli)
UniBasel Contributors:Loss, Georg and Braun-Fahrländer, Charlotte and Frey, Urs Peter
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Blackwell
ISSN:0269-5022
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:22
Deposited On:08 Nov 2012 16:13

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