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Determinants of change in airway reactivity over 11 years in a population study (SAPALDIA)

Curjuric, I. and Zemp Stutz E., and Dratva, J. and Ackermann-Liebrich U., and Bridevaux, P. O. and Bettschart, R. W. and Brutsche, M. and Frey, M. and Gerbase, M. W. and Knöpfli, B. and Künzli, N. and Pons, M. and Schwartz, J. and Schindler, C. and Rochat, T.. (2011) Determinants of change in airway reactivity over 11 years in a population study (SAPALDIA). The European respiratory journal, 37. pp. 492-500.

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Official URL: http://edoc.unibas.ch/dok/A6002161

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Abstract

We investigated determinants of change in bronchial reactivity in SAPALDIA, a population-based cohort with wide age range (29-72 years at follow-up). The role of sex, age, atopic status, smoking and BMI on percent change in bronchial reactivity slope from baseline value was analysed in 3005 participants with methacholine tests in 1991 and 2002 and complete covariate data. Slope was defined as percentage decline in FEV1 from its maximal value per mumol methacholine. Bronchial hyper-reactivity prevalence fell from 14.3% to 12.5% during follow-up. Baseline age was non-linearly associated to change in reactivity slope: participants below age 50 years experienced a decline, those above an increase during follow-up. Atopy was not associated with change, but accentuated the age pattern (pinteraction=0.038). Smoking significantly increased slope by 21.2%, as did weight gain (2.7% increase per BMI unit). Compared to persistent smokers, quitters before baseline or during follow-up experienced a significant decrease in slope (-27.7% and -23.9%, respectively). Differing, but not statistically different age-relationships and effect sizes for smoking and BMI between sexes were found. Mean bronchial reactivity increases after age 50 years, possibly due to airway remodelling or ventilation perfusion disturbances related to cumulating lifetime exposures
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Air Pollution and Health (Künzli)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Air Pollution and Health (Künzli)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Biostatistics > Biostatistics - Frequency Modelling (Schindler)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Society, Gender and Health > Gender and Health (Zemp Stutz)
UniBasel Contributors:Curjuric, Ivan and Ackermann-Liebrich, Ursula A. and Schindler, Christian and Zemp Stutz, Elisabeth and Dratva, Julia and Künzli, Nino
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Munksgaard
ISSN:0903-1936
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Nov 2017 06:38
Deposited On:08 Nov 2012 16:09

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