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Anti-inflammatory and antimalarial meroterpenoids from the New Zealand ascidian Aplidium scabellum

Chan, S. T. and Pearce, A. N. and Januario, A. H. and Page, M. J. and Kaiser, M. and McLaughlin, R. J. and Harper, J. L. and Webb, V. L. and Barker, D. and Copp, B. R.. (2011) Anti-inflammatory and antimalarial meroterpenoids from the New Zealand ascidian Aplidium scabellum. The journal of organic chemistry, Vol. 76, H. 21. S. 9151-9160.

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Official URL: http://edoc.unibas.ch/dok/A6002108

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Abstract

Bioassay-directed fractionation of an extract of the New Zealand ascidian Aplidium scabellum has afforded the anti-inflammatory secondary metabolite 2-geranyl-6-methoxy-1,4-hydroquinone-4-sulfate (1) and a family of pseudodimeric meroterpenoids scabellones A (2)-D (5). The benzo[c]chromene-7,10-dione scaffold contained within scabellones A-D is particularly rare among natural products. The structures were elucidated by interpretation of NMR data. Scabellone B was also identified as a moderately potent, nontoxic inhibitor of Plasmodium falciparum
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:American Chemical Society
ISSN:0022-3263
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:22
Deposited On:08 Nov 2012 16:09

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