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Plasmodium sensitivity to artemisinins : magic bullets hit elusive targets

Ding, X. C. and Beck, H. P. and Raso, G.. (2011) Plasmodium sensitivity to artemisinins : magic bullets hit elusive targets. Trends in parasitology, Vol. 27, H. 2. S. 73-81.

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Official URL: http://edoc.unibas.ch/dok/A6002296

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Abstract

Artemisinins are efficacious antimalarial drugs widely employed as first-line treatment in endemic countries under the form of combined therapies. Different molecular modes of action have been postulated to explain the parasiticidal effect of these compounds; however, none has been unequivocally accepted, and their physiological relevance is still questioned. Similarly, no definite genetic determinant of Plasmodium sensitivity to artemisinins has been identified so far. A better understanding of the mode of action of artemisinins and the genetic basis of laboratory-induced or field-observed altered susceptibility is crucial for malaria control. In this review different models of artemisinins' molecular action are briefly presented, focusing on recent advances, and the evidence of potential association between various gene polymorphisms and artemisinin resistance is comprehensively reviewed
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Molecular Parasitology and Epidemiology (Beck)
UniBasel Contributors:Beck, Hans-Peter and Raso, Giovanna
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1471-4922
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:11 Oct 2012 15:32
Deposited On:11 Oct 2012 15:30

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