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Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood

Rochat, M. K. and Ege, M. J. and Plabst, D. and Steinle, J. and Bitter, S. and Braun-Fahrländer, C. and Dalphin, J.-C. and Riedler, J. and Roponen, M. and Hirvonen, M.-R. and Büchele, G. and Renz, H. and Lauener, R. and Krauss-Etschmann, S. and von Mutius, E. and Pasture Study group, . (2009) Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood. Clinical & experimental allergy, Vol. 40. S. 786-794.

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Official URL: http://edoc.unibas.ch/dok/A5843261

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Abstract

Summary Background Recent studies indicate that prenatal vitamin D intake may protect against the development of atopic diseases in young children. Vitamin D has been shown to induce tolerogenic antigen-presenting cells such as dendritic cells. Whether the allergy-protective potential of prenatal vitamin D is mediated through such mechanisms is, however, unknown. Objective To evaluate the association between prenatal vitamin D supplementation and tolerogenic antigen-presenting cells in cord blood (CB) as determined by mRNA measurement of immunoglobulin-like transcripts (ILT)3 and ILT4. Methods A prospective multi-centre birth cohort was established in rural areas of five European countries. Information on maternal exposures including vitamin D intake was collected by questionnaires during pregnancy. The gene expression of ILT3 and ILT4 was analysed by real-time PCR in the CB of 927 children. Maternal vitamin D supplementation was assessed in Finland and France (n=349). Results Maternal vitamin D supplementation during pregnancy was associated with an increase in the gene expression of ILT3 (P=0.012) and ILT4 (P>0.001). This association remained significant for ILT4 (P=0.020) and showed a positive trend for the gene expression of ILT3 (P=0.059) after multivariate analysis controlling for various confounders. Conclusions Vitamin D supplementation during pregnancy may increase the mRNA levels of ILT3 and ILT4 in CB. This finding may point towards an early induction of tolerogenic immune responses by maternal vitamin D intake
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Physical Hazards and Health (Röösli)
UniBasel Contributors:Braun-Fahrländer, Charlotte
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Blackwell
ISSN:0954-7894
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:11 Oct 2012 15:32
Deposited On:11 Oct 2012 15:28

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