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Traffic-related air pollution correlates with adult-onset asthma among never-smokers

Künzli, N. and Bridevaux, P. O. and Liu, S. and Garcia-Esteban R., and Schindler, C. and Gerbase, M. and Sunyer, J. and Keidel, D. and Rochat, T.. (2009) Traffic-related air pollution correlates with adult-onset asthma among never-smokers. Thorax, Vol. 64. S. 664-670.

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Official URL: http://edoc.unibas.ch/dok/A5843361

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Abstract

BACKGROUND: Traffic-related pollution is associated with asthma onset in children. Its effect on adult-onset asthma is poorly investigated. OBJECTIVE: We used the SAPALDIA cohort study to investigate associations between the 11-year change (1991-2002) in home outdoor traffic-related particulate matter up to 10 micrometers in diameter (TPM10) and asthma incidence. METHODS: Never-smokers without asthma at baseline (ages: 18-60 years in 1991) were eligible. Subjects reporting doctor's diagnosed asthma at follow-up were considered incident cases. TPM10 at baseline and follow-up was predicted and interpolated to subject's residences by dispersion models using emission and meteorological data. Cox proportional hazard models for time to asthma onset were adjusted (age, gender, baseline atopy, BMI, bronchial reactivity, maternal allergies). RESULTS: Among 2725 never-smokers, 41 reported asthma onset in 2002. Home outdoor TPM10 concentrations improved during the interval (mean: -0.6; range -9 to +7.2; IQR 0.6 microg/m3). Asthma incidence was associated with change in TPM10. The hazard ratio (1.30; 95%CI: 1.05 - 1.61) per 1 microg/m3 change in TPM10 (IQR) was not sensitive to further adjustments (education, workplace exposure, passive smoking, parental asthma or allergies, random area effects, lung function, or co-pollutants such as regional, secondary, total PM10, or proximity to busy roads). CONCLUSION: The data suggest a role for traffic-related pollution in adult-onset asthma. Space, time, and source-specific individual assignment of exposure to traffic-related pollution is a key strength of SAPALDIA. It may explain why findings were statistically significant despite the limited number of new cases. As traffic-related pollution prevails, the finding may be of substantial public health relevance.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Biostatistics > Biostatistics - Frequency Modelling (Schindler)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Environmental Exposures (Liu)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Air Pollution and Health (Künzli)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Air Pollution and Health (Künzli)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Physical Hazards and Health (Röösli)
UniBasel Contributors:Liu, Lee-Jane S. and Schindler, Christian and Keidel, Dirk and Künzli, Nino
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:British Medical Association
ISSN:0040-6376
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Mar 2013 11:08
Deposited On:11 Oct 2012 15:27

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