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Treatment of acute uncomplicated falciparum malaria with artemether-lumefantrine in nonimmune populations : a safety, efficacy, and pharmacokinetic study

Hatz, C. and Soto, J. and Nothdurft, H. D. and Zoller, T. and Weitzel, T. and Loutan, L. and Bricaire, F. and Gay, F. and Burchard, G. D. and Andriano, K. and Lefèvre, G. and De Palacios, P. I. and Genton, B.. (2008) Treatment of acute uncomplicated falciparum malaria with artemether-lumefantrine in nonimmune populations : a safety, efficacy, and pharmacokinetic study. American journal of tropical medicine and hygiene, Vol. 78. S. 241-247.

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Official URL: http://edoc.unibas.ch/dok/A6006860

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Abstract

The efficacy and safety of artemether-lumefantrine for the treatment of malaria in nonimmune populations are not well defined. In this study, 165 nonimmune patients from Europe and non-malarious areas of Colombia with acute, uncomplicated falciparum malaria or mixed infection including P. falciparum were treated with the six-dose regimen of artemether-lumefantrine. The parasitologic cure rate at 28 days was 96.0% for the per protocol population (119/124 patients). Median times to parasite clearance and fever clearance were 41.5 and 36.8 hours, respectively. No patient had gametocytes after Day 7. Treatment was well tolerated; most adverse events were mild to moderate and seemed to be related to malaria. There were few serious adverse events, none of which were considered to be drug-related. No significant effects on ECG or laboratory parameters were observed. In conclusion, the six-dose regimen of artemether-lumefantrine was effective and well tolerated in the treatment of acute uncomplicated falciparum malaria in nonimmune patients.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Travel Clinic (Neumayr)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Medicine > Travel Clinic (Neumayr)
UniBasel Contributors:Hatz, Christoph
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Williams and Wilkins
ISSN:0002-9637
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Mar 2013 11:08
Deposited On:11 Oct 2012 15:26

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