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Buruli ulcer disease : prospects for a vaccine

Huygen, K. and Adjei, O. and Affolabi, D. and Bretzel, G. and Demangel, C. and Fleischer, B. and Johnson, R. C. and Pedrosa, J. and Phanzu, D. M. and Phillips, R. O. and Pluschke, G. and Siegmund, V. and Singh, M. and van der Werf T. S., and Wansbrough-Jones M., and Portaels, F.. (2009) Buruli ulcer disease : prospects for a vaccine. Medical microbiology and immunology = Zeitschrift für medizinische Mikrobiologie und Immunologie, Vol. 198, H. 2. S. 69-77.

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Official URL: http://edoc.unibas.ch/dok/A5843157

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Abstract

Buruli ulcer disease (BUD), caused by Mycobacterium ulcerans, is a neglected bacterial infection of the poor in remote rural areas, mostly affecting children. BUD is a mutilating disease leading to severe disability; it is the third most common mycobacterial infection in immunocompetent people after tuberculosis and leprosy. It is most endemic in West Africa, but cases have been reported from more than 30 countries. Treatment with antibiotics is possible, long-lasting and requires injections; there are cases of treatment failures, and the disease is prone to resistance. A vaccine against M. ulcerans would protect persons at risk in highly endemic areas, and could be used as a therapeutic vaccine to shorten the duration of treatment and prevent relapses. There is considerable evidence supporting the notion that generation of a vaccine is feasible. This article reviews the present state of the art with special emphasis on the immunology of the infection and the prospects for development of a vaccine
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Molecular Immunology (Pluschke)
UniBasel Contributors:Pluschke, Gerd
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0300-8584
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 07:18
Deposited On:14 Sep 2012 06:43

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