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Differential var gene expression in children with malaria and antidromic effects on host gene expression

Kalmbach, Y. and Rottmann, M. and Kombila, M. and Kremsner, P. G. and Beck, H. P. and Kun, J. F.. (2010) Differential var gene expression in children with malaria and antidromic effects on host gene expression. Journal of Infectious Diseases, Vol. 202, no. 2. S. 313-317.

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Official URL: http://edoc.unibas.ch/dok/A5842869

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Abstract

Among 62 children with mild malaria, cerebral malaria, or severe malarial anemia, we analyzed the transcription of different var gene types. There was no difference in parasitemia level or body temperature between groups. However, a significantly different expression pattern was observed in children with cerebral malaria, compared with that in patients in the other 2 groups: children with cerebral malaria had lower expression of the upsA subtype but higher expression of the upsB and upsC subtypes. Furthermore, expression of human genes responsive to tumor necrosis factor and hypoxia correlated with distinct ups types
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Molecular Parasitology and Epidemiology (Beck)
UniBasel Contributors:Beck, Hans-Peter
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Oxford University Press
ISSN:0022-1899
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Jun 2012 06:55
Deposited On:08 Jun 2012 06:47

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