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The psychological development of children of epileptic parents (Part 1: Study design and comparative findings ; Part 2: The differential impact of intrauterine exposure to anticonvulsant drugs and further influential factors)

Steinhausen, H. C. and Lösche, G. and Koch, S. and Helge, H.. (1994) The psychological development of children of epileptic parents (Part 1: Study design and comparative findings ; Part 2: The differential impact of intrauterine exposure to anticonvulsant drugs and further influential factors). Acta paediatrica, Vol. 83, H. 9 , S. 955-960 (part 1); S. 961-966 (part 2). pp. 955-966.

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Official URL: http://edoc.unibas.ch/dok/A5838960

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Abstract

Part 1: We studied the genetic, neurobiological, teratogenic and psychosocial risks for the development of children born to epileptic parents in (a) children of epileptic mothers with intrauterine exposure to anticonvulsants, (b) children of epileptic mothers without intrauterine exposure to anticonvulsants and (c) children of epileptic fathers. In addition, three matched control groups were also considered. The longitudinal design of the study covered newborns to children of six years of age. A wide range of developmental and psychological tests and a structured interview for the assessment of psychiatric symptoms were used. It was shown that teratogenic factors are operant, whereas there was no indication that the condition of epilepsy in the parents per se had any effect on the developmental outcome of the children. The possible teratogenic effect of anticonvulsants should be studied in more detail. Part 2: After obtaining evidence that tetratogenic effects were operant in a sample of children born to epileptic mothers, we analyzed the effects of type of medication and further influential factors. Children with prenatal exposure to polytherapy had significantly lower scores than controls for a large number of psychological tests. In addition to polytherapy, there were even stronger effects of socioeconomic status and sex was found to be less influential than polytherapy. Among further epilepsy variables, only seizure frequency of the mother during pregnancy had a modest impact on the child's developmental outcome, whereas a score of obstetric abnormality was less effective in predicting developmental outcome, as measured and defined by various standardized psychological tests.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Clinical Child and Adolescent Psychology (Schneider)
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Taylor & Francis
ISSN:0803-5253
Note:Authors Part 1: Steinhausen, H. C.; Lösche, G.; Koch, S.; Helge, H. ; Authors Part 2: Lösche, G.; Steinhausen, H. C.; Koch, S.; Helge, H. -- Publication type according to Uni Basel Research Database: Journal article
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Last Modified:30 Jun 2016 10:48
Deposited On:08 Jun 2012 06:45

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