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Der Mikroagglutinationstest : ein einfaches und sensitives Verfahren zur Serodiagnostik von Pertussisinfektionen

Heininger, U. and Stehr, K. and Schmitt-Grohe, S. and Uberall, M. and Lorenz, C. and Rost, R. and Cherry, J. D.. (1995) Der Mikroagglutinationstest : ein einfaches und sensitives Verfahren zur Serodiagnostik von Pertussisinfektionen. Klinische Pädiatrie, Vol. 207, H. 5. S. 277-280.

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Official URL: http://edoc.unibas.ch/dok/A5839207

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Abstract

The microagglutination assay is a useful method for the diagnosis of B. pertussis infections. In a group of 30 patients with culture proven pertussis 27 (90%) had < or = fourfold increases in titers between acute and convalescent phase serum specimens. The microagglutination test offers several advantages over other more sophisticated B. pertussis antibody tests: only 50 microliters of serum is required, it is a standardized test, which doesn't require specialized technical expertise or equipment, it is easy to perform and good results are noted in a broad age range of patients. Disadvantages of the microagglutination test are: two separate serum specimens are necessary (acute and convalescent phase), the test does not differentiate IgA and IgG antibodies and the temporal association with recent immunization can lead to false positive results. In our opinion the microagglutination test is a useful method for the diagnosis of B. pertussis infections. This is especially true in cases where more sophisticated serologic tests such as ELISA can not be performed immediately but physicians and patients expect to get a result quickly.
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB)
03 Faculty of Medicine
UniBasel Contributors:Heininger, Ulrich
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Enke
ISSN:0300-8630
Note:Note: Engl. Übersetzung des Titels: The microagglutination test - simple and sensitive procedure for serodiagnosis of pertussis infections -- Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Jun 2012 06:30
Deposited On:22 Mar 2012 14:19

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