Lee, Jun. Scaling proprioceptor gene transcription by retrograde NT3 signaling. 2011, PhD Thesis, University of Basel, Faculty of Science.
Official URL: http://edoc.unibas.ch/diss/DissB_9615
This study was aimed at a genome-wide analysis of target-induced gene cascades in proprioceptive afferents with the goal of defining in an unbiased way the pathways linking target-derived factors to central motor circuit assembly. We used gene expression profiling of purified proprioceptive afferents in combination with Affymetrix chip technology to study genes regulated by peripheral neurotrophin 3 (NT3). Data mining of our results demonstrates that several parallel signaling pathways influence differentiation of proprioceptive afferents retrogradely. These findings therefore suggest that NT3 does not solely induce the transcriptional program orchestrated by the ETS transcription factor Er81 in proprioceptive afferents, but also triggers additional pathways which may influence connectivity of motor circuits in the spinal cord retrogradely.
|Committee Members:||Caroni, Pico|
|Faculties and Departments:||05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Arber)|
|Bibsysno:||Link to catalogue|
|Number of Pages:||127 S.|
|Last Modified:||30 Jun 2016 10:42|
|Deposited On:||12 Oct 2011 11:44|
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