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Aqueous oxidation of alcohols catalyzed by artificial metalloenzymes based on the biotin-avidin technology

Thomas, Christophe M. and Letondor, Christophe and Humbert, Nicolas and Ward, Thomas R.. (2005) Aqueous oxidation of alcohols catalyzed by artificial metalloenzymes based on the biotin-avidin technology. Journal of Organometallic Chemistry, 690 (20). pp. 4488-4491.

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Official URL: http://edoc.unibas.ch/dok/A5254485

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Abstract

Based on the incorporation of biotinylated organometallic catalyst precursors within (strept)avidin, we have developed artificial metalloenzymes for the oxidation of secondary alcohols using tert-butylhydroperoxide as oxidizing agent. In the presence of avidin as host protein, the biotinylated aminosulfonamide ruthenium piano stool complex 1 (0.4 mol%) catalyzes the oxidation of sec-phenethyl alcohol at room temperature within 90 h in over 90% yield. Gel electrophoretic analysis of the reaction mixture suggests that the host protein is not oxidatively degraded during catalysis.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Ward, Thomas R. R.
Item Type:Article, refereed
Publisher:Elsevier
ISSN:0022-328X
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:24 Apr 2017 13:38
Deposited On:22 Mar 2012 14:07

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