Klein, Gerard and Humbert, Nicolas and Gradinaru, Julieta and Ivanova, Anita and Gilardoni, Francois and Rusbandi, Untung E. and Ward, Thomas R.. (2005) Tailoring the Active Site of Chemzymes by Using a Chemogenetic-Optimization Procedure: Towards Substrate-Specific Artificial Hydrogenases Based on the Biotin–Avidin Technology. Angewandte Chemie International Edition, 44 (47). pp. 7764-7767.
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Official URL: http://edoc.unibas.ch/dok/A5254454
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Abstract
The combination of chemical- with genetic-optimization strategies (i.e. chemogenetic) allows the production of artificial hydrogenases based on the biotin–avidin technology. In the spirit of enzymes, second-coordination-sphere interactions between the host protein (streptavidin) and the substrate (an olefin) allow fine-tuning of the selectivity to produce either R or S hydrogenation products.
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward) |
|---|---|
| UniBasel Contributors: | Ward, Thomas R. R. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Wiley |
| ISSN: | 1433-7851 |
| e-ISSN: | 1521-3773 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: | |
| Last Modified: | 24 Apr 2017 13:19 |
| Deposited On: | 22 Mar 2012 14:07 |
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