Design and Synthesis of Compartmental Ligands and their Complexes for the Production of Catalytic Antibodies

The synthesis and coordination properties of mixed N,O-compartmental ligands is described. Macrocyclic ligands 8 and 15 were designed to mimic transition-state analogs for the production of catalytic antibodies for C−H activation reactions. Reaction of 8 with vanadyl cations yields the dinuclear complex 9, which was characterized by X-ray crystallography. Amputated ligands 17 and 18 react with various transition-metal cations to yield complexes designed to act as coenzymes for the catalytic antibodies. The Ni complex of 17 (19) was also structurally characterized by X-ray crystallography.