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Das Vorkommen von CD44 und seinen Isoformen unter orthologischen und pathologischen Bedingungen = Occurrence of CD44 and its isoforms under orthological and pathological conditions

Terpe, A. and Franke, F. and Stark, H. and Gustmann, C. and Mackay, C. and Marston, W. and Günthert, U.. (1993) Das Vorkommen von CD44 und seinen Isoformen unter orthologischen und pathologischen Bedingungen = Occurrence of CD44 and its isoforms under orthological and pathological conditions. Verhandlungen der Deutschen Gesellschaft für Pathologie, 77. S. 276-281.

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Official URL: http://edoc.unibas.ch/dok/A5249247

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Abstract

Variant isoforms of CD44 have been strongly implicated in malignant transformation and cancer metastasis. To ascertain the pattern of expression of these isoforms in human normal, fetal and tumor tissues (breast carcinomas, renal cell carcinomas, malignant melanomas, colon carcinomas, non-Hodgkin-lymphomas, neuroblastomas and brain tumors), we generated monoclonal antibodies against CD44 variant regions. Monoclonal antibodies were produced against variant regions encoded by exons 4v, 6v and 9v. CD44 variant isoforms are expressed on normal epithelial cells in a different pattern. Regions of epithelia that expressed the highest levels of the variant isoforms were those with a high rate of cell division. CD44 variant isoforms were not expressed by all investigated tumors (not by malignant melanomas, brain tumors and neuroblastomas). It is interesting that the expression of CD44 isoforms in non-Hodgkins lymphomas and colon carcinomas shows possibly a correlation with malignancy.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Neuro- und Muskelpathologie (Frank)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Neuro- und Muskelpathologie (Frank)
03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Allgemeine Pathologie (Tolnay)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Allgemeine Pathologie (Tolnay)
03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Ehemalige Einheiten Querschnittsfächer (Klinik) > Allgemeine und spezielle Pathologie (Oberholzer)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Ehemalige Einheiten Querschnittsfächer (Klinik) > Allgemeine und spezielle Pathologie (Oberholzer)
UniBasel Contributors:Günthert, Ursula
Item Type:Article, refereed
Bibsysno:Link to catalogue
Note:Also published in: Aktuelle Pathologie der Prostata und der ableitenden Harnwege. - Stuttgart : Gustav Fischer, 1993. - S. 276-281 -- Publication type according to Uni Basel Research Database: Journal item
Last Modified:07 Aug 2015 12:05
Deposited On:22 Mar 2012 13:59

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