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Targeting lipid signalling in cancer

Cmiljanović, Vladimir. Targeting lipid signalling in cancer. 2010, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_9005

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Abstract

Phosphoinositide 3-kinases (PI3Ks) play an important role in a variety of cellular activities, including mitogenic signalling and cell survival, cytoskeletal remodelling, metabolic control, proliferation and vesicular trafficking. Consistent with their function in cell survival and growth, the gene for the class Iα PI3K catalytic subunit is a common site of cancer mutations. Ongoing structural studies of these enzymes and the complexes they make with their regulatory subunits have helped to clarify the mechanistic basis of this role in tumor development. The broad spectrum of biological activities associated with various isotypes of class I PI3Ks has led to an intense search for isotype-specific inhibitors as tools in mammalian cell biology and for therapeutic application.
Advisors:Giese, Bernd
Committee Members:Pfaltz, Andreas
Faculties and Departments:05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Bioorganische Chemie (Giese)
UniBasel Contributors:Giese, Bernd and Pfaltz, Andreas
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:9005
Thesis status:Complete
Bibsysno:Link to catalogue
Number of Pages:304 S.
Language:English
Identification Number:
Last Modified:22 Jan 2018 15:51
Deposited On:21 May 2010 08:15

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