Izergina, Natalya. Postembryonic development of amplifying neuroblast lineages in the "Drosophila" brain : proliferation, differentiation and projection patterns. 2010, PhD Thesis, University of Basel, Faculty of Science.
Official URL: http://edoc.unibas.ch/diss/DissB_8952
We analyzed the type and fate of cells generated in the DM lineages. With a combination of neuronal and glial cell markers we show that the DM lineages generate not only neurons but also glial cells. The DM neuroblasts thus represent the first identified multipotent precursor cells in the fly brain during postembryonic development. We also show that the adult-specific neurons of each DM lineage form several spatially separated axonal fascicles some of which project along larval brain commissural structures which are primordia of future adult midline neuropil. By taking advantage of a DM-specific Gal4 reporter line we identify and follow DM-derived neuronal cells into early pupal stages and demonstrate that neurons of the DM lineages make a major contribution to the developing central complex, in that the numerous columnar elements are likely to be DM lineage-derived. These findings suggest that the amplification of proliferation which characterizes DM lineages may be an important requirement for generating the large number of neurons required in highly complex neuropil structures such as the central complex in the Drosophila brain.
|Committee Members:||Affolter, Markus|
|Faculties and Departments:||05 Faculty of Science > Departement Biozentrum > Neurobiology > Molecular Zoology (Reichert)|
|Bibsysno:||Link to catalogue|
|Number of Pages:||94 Bl.|
|Last Modified:||30 Jun 2016 10:41|
|Deposited On:||30 Apr 2010 10:43|
Repository Staff Only: item control page